spoilDon't spoil the movie by telling me what happens!
ruinI put too much salt in the sauce and ruined it.
disfigureHer face was disfigured by the scar.
sourOur friendship soured after the argument, and we just drifted apart.
poisonThe long dispute has poisoned relations between the two countries.
mess upinformalLaurie's illness has completely messed up all our holiday plans.
screw upinformalThat new software has really screwed up my computer.